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Alpha-2-macroglobulin (A2M) is a nonimmunoglobulin protein found in plasma protein. This substance can inactivate many proteinases that degrade chondrocytes (cartilage cells), which contribute to osteoarthritis (OA). How does A2M work? Through injection or administration of A2M protease, alpha-2-macroglobulin is inhibited. A2M can stop progression of OA by...