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Physical therapy is a safe and effective treatment for managing rheumatoid arthritis (RA) and osteoarthritis (OA), as well as other joint problems. Physical therapy involves two main types of treatment: passive treatments and active treatments. Both types of treatment can significantly reduce the pain associate...

Alpha-2-macroglobulin (A2M) is a nonimmunoglobulin protein found in plasma protein. This substance can inactivate many proteinases that degrade chondrocytes (cartilage cells), which contribute to osteoarthritis (OA). How does A2M work? Through injection or administration of A2M protease, alpha-2-macroglobulin is inhibited. A2M can stop progression of OA by...